Finally, the most highly differentially expressed genes post-treatment in Irf1−/− mutants compared to B6 controls are mast cell proteases, Mcpt1 and Mcpt2 (Fig. 5C), which have been shown to recruit Gr1+ Cd11b+ cells in response to intestinal dysbiosis and promote their tumor-promoting capabilities in CA-CRC49. This evidence concerns the gene IRF1 and neoplasm.