IRF1 and cancer: These studies showed that transfer of Irf1−/− mutant BM into irradiated B6 mice (CD45.1) confers significant CA-CRC susceptibility, at a level similar to that seen in Irf1−/− mutant animals receiving Irf1−/− mutant BM (Fig. 5F), whereas transfer of B6 (CD45.1) BM into irradiated Irf1−/− mutant mice conveys significant protection against CA-CRC (Fig. 5F).