IDH1 and cancer: Consistent with the effects of IDH1 mutation in terms of catalytic activities of αKG-dependent histone lysine demethylases, the levels of global histone H3 lysine 4 trimethylation (H3K4me3) and lysine 27 trimethylation (H3K27me3) were elevated in mut-IBOs, compared to wt-IBOs (Supplementary Fig. 3B) as previously reported in cancer cells15,16.