Among the 418 variants, we observed 180 non-synonymous SNVs belonging to 174 protein coding genes including kinases such as HRAS and MAP2K1 (Fig. 2a,c,d) Pan-cancer expression of HRAS and MAP2K1 mutations from TCGA is represented in Supplementary Figs. S2 and S3. Here, MAP2K1 is linked to cancer.