LCN2 and colitis: Furthermore, only flagellin protected against microbiota encroachment (Fig. 6c, d), decreased microbiota pro-inflammatory potential (Fig. 6e, f) and prevented colitis, as revealed by decreased spleen weight, increase in colon length and weight, decrease in fecal level of lipocalin-2 and decrease in colonic histopathological score (Fig. 6g–l and Supplementary Fig. 5).