ICAM1 and systemic sclerosis: Also, fibroblasts from HC co-cultured with trained macrophages did not show any differences in the cytokine production levels (Supplementary Fig. 7b) or fibrosis markers, except for Icam-1 that was upregulated in the BCG-macrophages-fibroblasts co-culture but to a lesser extent than that observed in the co-culture with SSc-fibroblasts (Supplementary Fig. 8).