Subsequently, ChIP assay was performed and we observed that the YAP1-snail1 complex indeed bound to the promoter of CDH1 at approximately −300 bp and, when we overexpressed YAP1, the expression was stronger than before (Fig. 5 n, o).These results indicated that CLDN6 activated the expression of related oncogenes by increasing YAP1 nuclear translocation, thus accelerating the proliferation of GC cells. This evidence concerns the gene SNAI1 and gastric cancer.