In MKN28 and AGS cell lines, western blot assay showed that p-LATS and p-YAP1 levels were increased significantly in the sh-CLDN6 group (Fig. 5d).The increased levels of p-YAP1 led to decreased YAP1 entry into the nucleus, thereby inhibiting the development of gastric cancer (Fig. 5e). The gene discussed is CLDN6; the disease is gastric cancer.