Subsequently, ChIP assay was performed and we observed that the YAP1-snail1 complex indeed bound to the promoter of CDH1 at approximately −300 bp and, when we overexpressed YAP1, the expression was stronger than before (Fig. 5 n, o).These results indicated that CLDN6 activated the expression of related oncogenes by increasing YAP1 nuclear translocation, thus accelerating the proliferation of GC cells. Here, CLDN6 is linked to gastric cancer.