A group of alterations in SCLC appears to converge on genes encoding epigenetic regulators, including CREBBP/EP300 (cAMP response element-binding (CREB)-binding protein/E1A-associated p300), KMT2A and KMT2D (lysine methyltransferase 2A and 2D, respectively), KDM6A (lysine demethylase 6A), and several components of the polybromo-associated BRG/BRM-associated factor (PBAF) complex, including PBRM1 (polybromo 1), ARID1A and ARID2 (AT-rich interactive domain-containing protein 1A and 1D, respectively), and CHD7 (chromodomain-helicase-DNA-binding protein 7)20–22,39. The gene discussed is KDM6A; the disease is small cell lung carcinoma.