Importantly, these subtypes can be linked to specific biomarkers that are either targets of specific drugs or predictors of drug response, for example, DLL3 (a membrane target for the antibody-drug conjugate Rova-T) in SCLC-A and AURKA (a kinase target for alisertib) in SCLC-N7,8. Here, DLL3 is linked to small cell lung carcinoma.