MYC and small cell lung carcinoma: Similarly, inactivation of the MYC binding protein MAX in MYC-high SCLC caused synthetic lethality with BRG1 inhibition101, and inhibition of arginine synthesis with pegylated arginine deiminase (ADI-PEG-20) selectively suppressed the growth of MYC-driven tumors in GEMMs, human cell lines, and patient-derived xenografts from a relapsed patient102.