The heterogeneity in SCLC was first noted years ago by Carney et al., who described the ‘variant’ form of cells with c-MYC amplification, partial or complete loss of neuroendocrine differentiation, and partial epithelial-to-mesenchymal transition phenotype, as opposed to the ‘classic’ sphere/aggregate-forming neuroendocrine cells9. Here, MYC is linked to small cell lung carcinoma.