ALMS1 (Alstrom syndrome gene), ASPM (abnormal spindle-like microcephaly-associated protein), and PDE4DIP (phosphodiesterase 4D interacting protein) bind to microtubules and play a role in the formation of microtubule-based structures, including the centrosome and mitotic spindle58–60. This evidence concerns the gene ASPM and Alstrom syndrome.