More recently, novel potential oncogenes and tumor suppressor genes have been reported in multiple myeloma, e.g. PTPN11, PRKD2, IDH1/2, HUWE1, and UBR5 in addition to the known driver genes in multiple myeloma, i.e. KRAS, NRAS, BRAF, TP53, FAM46C, DIS3, and more8. Here, HUWE1 is linked to AL amyloidosis.