More recently, novel potential oncogenes and tumor suppressor genes have been reported in multiple myeloma, e.g. PTPN11, PRKD2, IDH1/2, HUWE1, and UBR5 in addition to the known driver genes in multiple myeloma, i.e. KRAS, NRAS, BRAF, TP53, FAM46C, DIS3, and more8. This evidence concerns the gene HUWE1 and plasma cell myeloma.