They then tested the strain’s therapeutic efficacy in orthotropic HCC and showed that it could inhibit tumor proliferation and metastasis, reduce the amount of tumor microvasculature, increase the CD4+/CD8+ T-cell populations and the expression levels of several inflammatory cytokines (including IFN-γ and TNF-α), and downregulate TGF-β, regulatory T cells, and vascular endothelial growth factor (VEGF) expression149. This evidence concerns the gene TNF and neoplasm.