INS and type 2 diabetes mellitus: However, insulin secreted from T2DM serum-treated islets at 11.1 mM glucose was significantly greater than that at 3.3 mM glucose, whereas insulin released from ALS-T2DM serum-treated islets at 11.1 mM glucose did not significantly differ from that at 3.3 mM glucose due to increased basal insulin release (Fig. 5 C and D).