Ifitm3 knockout mice show enhanced morbidity after infection with IAV, alphaviruses, and flaviviruses (33, 34, 35, 36), and in humans, single nucleotide polymorphisms in IFITM3, which may act by altering IFITM3 expression or subcellular distribution, have been associated with an increase in morbidity in IAV and HIV-1 infections (recently reviewed by references 37 and 38). This evidence concerns the gene IFITM3 and HIV-1 infection.