RHO and retinal degeneration: We examined two complementary models of progressive retinal degeneration: the knock-out mouse lacking the γ-subunit of the rod G protein transducin (the Gγ1-/- mouse; Lobanova et al., 2008) and the knock-in mouse bearing a single copy of the P23H mutation in rhodopsin (the P23H mouse; Sakami et al., 2011).