SERPING1 and hyperinsulinemic hypoglycemia, familial, 4: It is important to note that cortisone and antihistamines are clearly ineffective in some types of angioedemas (HAE-C1-INH, HAE with normal C1-INH, angioedemas caused by acquired C1-INH deficiency, angioedemas caused by ACE inhibitors) and only questionably effective in others.