Other binding partners of RUNX1-ETO include proteins of the HDAC, DNA methyltransferase (DNMT) and protein arginine methyltransferase (PRMT) families, which are involved in the modeling of chromatin structure [20–22], and genome-wide changes in transcription factor binding have been shown for the depletion of RUNX1-ETO in AML cells [23]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.