The presence of fusion genes BCR-ABL1 and NUP214-XKR3 in CML cell line K-562 suggests an early and simultaneous generation of both translocations while juxtaposition and subsequent co-amplification of BCR-ABL1 and MIR17HG as reported here may have occurred afterwards (S9C Fig) [76]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.