BCL2 and cancer: Through this study, we illustrate a computational workflow aimed at providing insight into: (i) the expression of pro-survival Bcl-2 members and their interactors in a certain cancer type, (ii) elucidating the functional interaction between them, and predicting the effects of substitutions on these interactions, and (iii) identifying alterations which could impact on the turnover of the protein, altering its structural stability.