EIF4E and cancer: Since their discovery (Pause et al., 1994) as repressors of eukaryotic translation initiation factor 4E (eIF4E), eIF4E-binding proteins (4E-BPs) have been implicated in cancer progression (Petroulakis et al., 2009), innate immunity (Colina et al., 2008), circadian rhythms (Cao et al., 2013), learning and memory (Banko et al., 2005, Banko et al., 2007), and, more recently, autism spectrum disorders (ASDs) (Gkogkas et al., 2013).