Previous work by our group and others strongly implicated soluble Aβ and tau separately in synapse dysfunction and loss in AD (Spires-Jones and Hyman, 2014, Klein, 2013, Koffie et al., 2009, Koffie et al., 2012, Kopeikina et al., 2012, Mucke and Selkoe, 2012, Spires-Jones et al., 2017). Here, MAPT is linked to Alzheimer disease.