After 16 weeks, they found that the ApoE−/−Ppia−/− mice developed significantly reduced atherosclerosis compared with ApoE−/− mice, and CyPA deficiency was associated with decreased vascular cell adhesion molecule 1 (VCAM-1) expression, ROS, inflammation, ECs activation and apoptosis [57]. The gene discussed is VCAM1; the disease is atherosclerosis.