In a cohort of patients (n = 111) with confirmed ATTRwt disease, biceps tendon rupture was observed in 37 patients, representing 33% of the cohort, and was a significantly more common finding in patients with TTR cardiac amyloidosis than patients with other etiologies of HFpEF.19 The authors of this estimate the positive predictive value of biceps tendon rupture to be 66% (LR 13.3) for the diagnosis of ATTRwt assuming a 13% prevalence of ATTRwt among those with HFpEF. The gene discussed is TTR; the disease is cardiac amyloidosis.