A more recent prospective study among 120 hospitalized older patients with HFpEF and increased ventricular wall thickness (>12 mm) on echocardiography used nuclear scintigraphy to screen for transthyretin cardiac amyloidosis, revealing diffuse myocardial retention of the radiotracer, DPD, consistent with ATTRwt cardiac amyloidosis in 13% of the cohort.6 In this study, the patients with ATTRwt cardiac amyloidosis were also on average older than those with other etiologies of HFpEF with a mean age of 86 vs 81 years. This evidence concerns the gene TTR and cardiac amyloidosis.