REN and acute kidney injury: Renin‐angiotensin‐aldosterone system inhibitors (ie, Angiotensin Converting Enzyme [ACE] inhibitors, Angiotensin II Receptor Blocker [ARB], aldosterone inhibitors): Renin‐angiotensin‐aldosterone system (RAAS) inhibitors are a cornerstone of guideline‐directed medical therapy post‐ACS, especially if left ventricular dysfunction is present.37 Older adults are at higher risk of acute kidney injury, and should be closely monitored for worsening renal dysfunction and hyperkalemia.