Urinary albumin creatinine ratio (uACR) was increased at 20 weeks in both knockdown and control groups after STZ induction with evidence of mild glomerulosclerosis on histological examination, but no statistical differences were observed between them (Figure 3C,D) showing that the progression of diabetic nephropathy was not attenuated by podocyte GSK3α knockdown. This evidence concerns the gene ALB and glomerulosclerosis.