CXCL8 and chronic obstructive pulmonary disease: This is in line with nicotine‐mediated inhibition of IL‐6 production in human brain astrocytes in a dose‐dependent manner.58 PG with or without nicotine induced significant IL‐8 release by both healthy and COPD donors compared to untreated controls, while no changes in PGE2 in any of the groups were observed.