CXCL8 and chronic obstructive pulmonary disease: These data demonstrate that acute exposure to e‐cig aerosols containing PG and PG with nicotine in a human 3D model of EpiAirway tissue promotes differential release of pro‐inflammatory mediators, such as IL‐6, IL‐8, and prostaglandin E2 (PGE2) in the normal (healthy) versus diseased state (COPD).