Using the ELISA assay, we found that the serum levels of Cyr61 were not altered in total AOSD patients (171.8 ± 63.8 pg/ml, n = 60) compared to those of HC (168.2 ± 54.9 pg/ml, n = 34, p > 0.05) (Supplementary Figure 1). The gene discussed is CCN1; the disease is adult-onset Still disease.