CCN1 and Splenomegaly: As shown in Figure 3, the levels of Cyr61 were significantly higher in AOSD patients who did not have fever, skin rash, sore throat, arthralgia, and lymphadenopathy compared with patients who had these clinical manifestations (p < 0.05); however, there was no significant difference of serum levels of Cyr61 between patients with or without splenomegaly, pneumonia, pleuritis, pericarditis, and myalgia.