TNF and adult-onset Still disease: To our knowledge, the inflammatory stimuli, such as TNF-α, IL-1β, IL-6, and IL-17, which were increased in the serum of AOSD patients, promoted Cyr61 expression (15, 18, 33); however, non-parametric Spearman correlation analysis revealed that the serum levels of Cyr61 were inversely correlated with the levels of IL-1β, IL-6, and IL-17 (Figure 4).