KLF6 is reputed as tumor suppressor since numerous reports demonstrate its frequent genomic loss or down-regulation, implying a functional inactivation, in a broad range of human cancers such as glioblastoma, hepatocellular carcinoma, gastric carcinoma, colorectal, prostate, ovarian, breast, and non-small-cell lung cancers (Narla et al., 2001; Kimmelman et al., 2004; Kremer-Tal et al., 2004; Narla et al., 2007; Bureau et al., 2009; DiFeo et al., 2009; Tetreault et al., 2013). This evidence concerns the gene KLF6 and non-small cell lung carcinoma.