In this sense, it has been shown that prolonged expression of KLF6-wt, but not KLF6-sv1, induced a senescent-like phenotype in two cell lines derived from glioblastoma: LN229 (glioblastoma cell line) and BTSC23 (Masilamani et al., 2017). Here, KLF6 is linked to glioblastoma.