Strikingly, increased expression of KLF6 in this cell line was able to induce a significant increase in the proportion of SA-β-Gal cells positive (7.86 ± 1.47 and 8.20 ± 1.47% doses, respectively, p < 0.05, Figures 3G,I), suggesting that KLF6 tumor suppressor role could be related to the induction of the cellular senescence. Here, KLF6 is linked to neoplasm.