In line with previous works that confirmed a direct action of Shh on mitochondrial dynamics (Malhotra et al., 2016; Yao et al., 2017; Kaushal et al., 2018) and oxidative capacity (Alam et al., 2016; Yao et al., 2017) in post-mitotic or cancer cells, we observe a direct effect of Shh on mitochondria in embryonic cells. Here, SHH is linked to cancer.