CD4 and hyperinsulinemic hypoglycemia, familial, 4: The number of CD4+ T cells and CD4/CD8 ratio were significantly increased following clinical initiation of weekly Prolastin therapy in patients with genetic α1PI deficiency (PIzz, n = 2, P = 0.01, and P < 0.04) (Figures 2A,B) (Bristow et al., 2010).