The risk locus 11q13, encoding the genes EMSY and LRRC32, has been associated with EoE (22), AD (23), and AA (24); other variants, such as in CAPN14, are more specific for EoE, as CAPN14 is specifically expressed in esophageal epithelial cells (14, 25). Here, CAPN14 is linked to Alzheimer disease.