In order to understand the global and specific involvement of IL-13 and epithelial cell response in the human EoE, AD, and AA, the three Th2 disease transcriptomes were compared separately with the transcriptomes of IL-13–stimulated primary epithelial cells isolated from the representative disease-affected tissues (esophagus, skin, or airway, respectively). Here, IL13 is linked to eosinophilic esophagitis.