IDH1 and central nervous system cancer: Based on the molecular profiles of gliomas, the mutation in the isocitrate dehydrogenase 1 (IDH1) gene has been identified to facilitate patient stratification and predict prognosis, along with other molecular markers including the 1p/19q co-deletion, methylguanine methyltransferase (MGMT) promoter methylation, tumor protein (TP) 53, and telomerase reverse transcriptase (TERT) promoters (9, 10).