Additionally, Jiang et al. recently demonstrated that CCAT1 interacts with the TFs tumor protein p63 (TP63) and SRY-box 2 (SOX2) to regulate the expression of the epidermal growth factor receptor (EGFR) in esophageal squamous cell carcinoma (ESCC) (84). Here, SOX2 is linked to esophageal squamous cell carcinoma.