Immediately after each fraction of primary tumor irradiation, intratumoral injections of canine CpG oligodeoxynucleotides [CpG ODNs; immune stimulatory toll-like receptor 9 (TLR9) agonists] were done; dogs were also orally dosed with 1-methyl-tryptophan [an indolamine-2,3 dioxygenase (IDO) inhibitor] (93). This evidence concerns the gene TLR9 and neoplasm.