LATS1 and neoplasm: To further determine whether FRY's interaction with the Hippo/YAP signaling pathway contributes to the observed FRY's tumor suppressive function, we used a siRNA targeting the LATS1 mRNA and reduced endogenous LATS1 protein levels by about 85% in the 231FRY cells (231FRY/LATS1KD) (Figure 5E).