To investigate the relationship between hypermethylation and MPCs in HNSCC, Rettori et al. examined the methylation patterns of 19 genes in 70 HNSCC cases (97), revealing that CCNA1 and TIMP3 hypermethylation were significantly connected with formation of SPT in HNSCC. This evidence concerns the gene CCNA1 and head and neck squamous cell carcinoma.