The lowest GI50s in both studies were in PAX3-FOXO1 positive RMS cell lines which had values (Supplementary Table 1) less than those seen in acute myeloid leukemia (AML) cell line models (in vitro GI50s ranging from 9 to 36nM) (36, 37). This evidence concerns the gene FOXO1 and acute myeloid leukemia.