NOS2 and urinary bladder neoplasm: The degree of infiltration of G-MDSC negatively correlated with the CD8 T cell infiltration in another study (57), in keeping with the T cell suppressive effects observed previously by Eruslanov et al. The MDSC present in bladder tumor have been shown to express high levels of immunosuppressive molecules such as Arginase 1, inducible nitric oxide synthases (iNOS) and PD-L1 and directly suppress T-cell proliferation reflecting their phenotype in the peripheral blood (58).