In the context of MIBC, a higher CD8/FoxP3 tumor infiltrating lymphocyte TIL ratio predicted better response to neoadjuvant chemotherapy though the density of either considered alone did not show this same correlation, with another study finding the same correlation with CD8/FoxP3 TIL ratio and survival post cystectomy (103, 104). The gene discussed is CD8A; the disease is neoplasm.