Production of M2 polarizing cytokines such as CCL2, IL-10, and TGF-β by bladder tumors has been demonstrated in various in vitro studies (26–28) and IL-10 production by bladder tumor cells has been shown to induce an immunosuppressive monocyte phenotype (Figure 3) (29). The gene discussed is TGFB1; the disease is urinary bladder neoplasm.