In fact, one study in human bladder cancer found that an increasing CD163/CD68 ratio (and therefore, increased M2 polarization as CD68 is a pan-macrophage marker) correlates with higher disease stage and vascularity (25) suggesting M2 polarized macrophages are responsible for the angiogenesis seen in bladder tumors. The gene discussed is CD68; the disease is urinary bladder neoplasm.