However, the picture in untreated or progressive bladder cancer is one of dominant Th2 polarization with Satyam et al. finding IFN-γ and IL-2 levels to be significantly lower in the blood of patients with bladder compared to healthy individuals with the inverse true of Th2 cytokines IL-4, IL5, and IL-10 (95). This evidence concerns the gene IFNG and urinary bladder cancer.