Lapuleucel-T, a dendritic cell based therapy using monocytes activated with recombinant GM-CSF linked to a HER2 peptide showed no statistically significant overall survival benefit or disease free survival benefit in a cohort of high risk HER2+ve bladder cancer patients in a phase 2 study (80, 81). The gene discussed is ERBB2; the disease is urinary bladder carcinoma.