TGFB1 and cancer: KEGG pathway analysis indicated that the three lncRNAs' functions were potentially associated with several cancer-related pathways, such as the “PI3K-Akt signaling pathway,” “TGF-β signaling pathway,” “Colorectal cancer,” and “P53 signaling pathway.” Current studies have shown that the PI3K-Akt pathway is activated in many types of cancers.