Previously, we found that cholesterol-conjugated miR-27 mimics could target VEGF-C (Vascular endothelial growth factor C) in vivo to inhibit tumor progression and angiogenesis in colorectal cancer (18), and it has also been reported that miR-27 could target the Wnt pathway (19), which is important for stemness maintenance in CCSCs (20). This evidence concerns the gene VEGFC and colorectal cancer.