Similarly, intense staining of CTSL in tumor endothelial cells was also noted in 55% (22/40) of GBC patients as compared to only 20% (12/60) in endothelial cells of controls (Figures 4D,E), indicating a remarkable increase in CTSL levels in GBC (p < 0.0001, Table 3). This evidence concerns the gene CTSL and neoplasm.