Additionally, specific components of the inflammatory tumor environment, for instance, Prostaglandin E2 (PGE2) produced by tumor cells in a mouse model, can affect the antitumor activity of T cells depending on IL-6, chemokine (C-X-C motif) ligand 1 (CXCL1), and granulocyte-colony stimulating factor (G-CSF) (66). This evidence concerns the gene IL6 and neoplasm.