Zhang et al. have further shown that YY1 prevents invasive metastasis of pancreatic ductal adenocarcinoma (PDAC) by downregulating the expression of MMP10 in a MUC4/ErbB2/p38/MEF2C dependent manner indicating the tumor suppressive role of YY1 in pancreatic cancer. This evidence concerns the gene YY1 and familial pancreatic carcinoma.