Recently, Huerta-Yepez et al., showed that YY1 is overexpressed in bone marrow derived multiple myeloma cells and its expression is correlated with poor prognosis and that depletion of YY1 in drug resistant MM cells sensitized them to bortezomib induced apoptosis (151) and it is likely that YY1 might also interact with factors other than RelA to promote MM growth. This evidence concerns the gene RELA and plasma cell myeloma.