Many genes influence HCC, TP53 tumor-suppressor gene, p16INK4A and Rb-associated with various risk factors have been largely reported (Bae et al., 2016; Buendia, 2000; Nishida & Fukuda, 2001; Peng et al., 2013; Wang et al., 2017; Zhang et al., 2014). The gene discussed is RB1; the disease is hepatocellular carcinoma.