In summary, our results demonstrated that lncRNAs AL671710.1, TRIM52-AS1, C1orf220, AC022762.2, DANCR, LINC01569, AC084018.1, and MIR194-2HG play an essential role in the HCC stage, and their targeted mRNA have key functions in HCC. Here, TRIM52 is linked to hepatocellular carcinoma.