A recent study conducted by Mosaet al. underscored the importance of studying the pathology of MVID by demonstrating the ability to rescue the defects present in MUNC18-2 (mutated in FHL5) knockdown mouse enteroids by expressing the human WT protein and not by the mutant FHL5 patient variant (P477L)36,44. The gene discussed is STXBP2; the disease is microvillus inclusion disease.