Remineralization with tri calcium phosphate with Fluoride showed increase in Ca/P mass percentage after demineralization similar to a study done by Namritha Patil et al. (16) who reported that TCP + fluoride based products perform better than CPP-ACP based products in remineralizing artificial enamel caries and Incorporation of fluoride into CPP-ACP compounds enhanced the remineralizing capacity. This evidence concerns the gene CPP and enamel caries.