In the functional enrichment analysis and literature survey, NFKB1, REL, RELA, TLR4, and TNFRSF1A are functionally contributing to RA These genes are also involved in pathways of innate immune system, cytokine signaling in immune system, NF kappa B signaling pathway, osteoclast differentiation, TNF signaling pathway, etc. The role of NF-κB in RA and its potential to become a therapeutic target is extensively reported. This evidence concerns the gene RELA and rheumatoid arthritis.