TNFRSF1A and rheumatoid arthritis: The R92Q mutation in TNFRSF1A could be involved in RA, as was seen in 5.2% of 135 patients with early arthritis (Aksentijevich et al., 2001; Nowlan et al., 2006; Dieude et al., 2007; Mewar and Wilson, 2011).