Figure 4 shows the expression of each gene in the sample. Among the NKPF category, NFKB1, REL, and RELA are found to be upregulated, with FC ≥ 1.2 in the RA sample, whereas NFKB2 and RELB are downregulated, with FC ≤ −1.2. The most upregulated gene is REL, with FC of 3.04, and the most downregulated gene is KPNA1, with FC of −1.85. It is interesting to note that the most upregulated gene, REL, falls into the NKPF group, whereas most downregulated gene, KPNA1, comes from the seed gene category. The gene discussed is NFKB2; the disease is rheumatoid arthritis.