Recent evidence suggests that DS dementia strongly correlates with overexpression of miR-155 on chromosome 21 with concomitant reduction of multiple CNS-functional targets, including BACH1, CoREST1, Cyclin D1, BCL6, BCL10, BIM, and SAPK4 (Tili et al., 2018) (Figure 2). Here, CCND1 is linked to dementia.