Five tagging single-nucleotide polymorphisms (SNPs) in the TNFRSF1B (TNF receptor superfamily member 1B) gene were studied in 1412 patients with RA, and the authors reported that carriers of the rs3397C/C, rs1061622G/G, and rs1061631A/A genotypes have increased risk for worse response to anti-TNFs. The gene discussed is TNFRSF1B; the disease is rheumatoid arthritis.