HLA-DQB1*03 and HLA-DRB1*13 have also been associated with A. alternata moderate to severe asthma in children, where HLA-DQB1*03 was reduced in frequency and HLA-DRB1*13 increased in frequency when compared to A. alternata mild asthmatic children (63). The gene discussed is HLA-DRB1; the disease is asthma.