As illustrated in Supplementary Figures S1A,B, both the percentage and absolute number of total MAIT cells and CD8+ MAIT cells were significantly reduced in peripheral blood samples from RRMS patients in remission and during exacerbations, as well as in PPMS subjects compared to HC (p < 0.0001). The gene discussed is CD8A; the disease is relapsing-remitting multiple sclerosis.