STX3 and neurodegenerative disease: The results suggest that the differences in exosome biogenesis and docking in tissue Mφs may be related to their proinflammatory functional status (Figure 4B) as we reported previously (26), that Rab GTPases not only regulate the pathogenesis of cancer and neurodegenerative diseases (58) but may also regulate inflammation functions of Mφ exosomes, and that syntaxin 3-identified homozygous likely deleterious variant (59) may regulate inflammatory Mφ exosomes.