These experiments were performed since previous studies reported vascular leakage in AG129 or STAT1–/– mice infected with the DENV2(NGC) strain (Johnson and Roehrig, 1999; Chen et al., 2008; Sung et al., 2019) and in IFNAR–/– mice infected with the DENV2 (PL046) strain (Beatty et al., 2015), but the effects of infection of IFNAR–/– C57BL/6 mice with the DEV2(NGC) strain were not studied. Here, IFNAR1 is linked to infection.