As a crucial element of the innate immune system, the NLRP3 inflammasome is not only an important component in host defense against pathogens (Allen et al., 2009; Wang et al., 2018; Negash et al., 2019) but is also involved in the progression of several inflammatory human diseases, such as gout and type 2 diabetes (So and Martinon, 2017; Wu et al., 2018). The gene discussed is NLRP3; the disease is glycogen storage disease VI.